Silymarin: A promising cardioprotective agent

Silymarin ‘milk thistle’ (Silybum marianum) plant, has been used for years treatment of different diseases such as liver and gallbladder disorders, protecting against snake bite insect stings, mushroom poisoning alcohol abuse. antioxidant, anti-lipid peroxidative, antifibrotic, anti-inflammatory, immunomodulatory, regeneration activities. The cardioprotective activities silymarin were primarily shown in cisplatin-induced cardiotoxicity rat models. These effects are due to replenishing endogenous antioxidant enzymes, suppressing neutrophil infiltration, reducing serum malondialdehyde the end product myocardial lipid peroxide. protects reperfusion damage inflammation by confirming anti-inflammatory actions. properties is considered responsible its cardio-protective mechanisms which heart remain largely unexplored. In this review, we will discuss detail silymarin.